Accession Number : AD0472302

Title :   ANTHRAX TOXIN: ITS EFFECT ON THE CENTRAL NERVOUS SYSTEM,

Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s) : Lincoln, Ralph E.

Report Date : SEP 1965

Pagination or Media Count : 16

Abstract : Anthrax toxin depressed the cerebral cortical electrical activity of both anesthetized and nonanesthetized monkeys. Concurrent recordings on a physiograph recorder revealed changes in their electrocardiogram and anoxic hypertension that progressed with the degree of intoxication to final cardiovascular collapse. Changes in cortical activity were either partial or complete, and in some cases cortical activity was followed by depression in cyclic patterns that appeared independent of the physiological changes. Those animals that died showed a respiratory failure that appeared to be of central origin involving the respiratory center of the brain. Survival with no changes in physiology or cortical activity occurred in monkeys pretreated and post-treated up to 8 hours with specific anthrax antisera. (Author)

Descriptors :   (*BACILLUS ANTHRACIS, TOXINS AND ANTITOXINS), (*TOXINS AND ANTITOXINS, BIOASSAY), (*CENTRAL NERVOUS SYSTEM, BACILLUS ANTHRACIS), MONKEYS, BLOOD PRESSURE, ELECTROENCEPHALOGRAPHY, NERVE IMPULSES, SURVIVAL(PERSONNEL), BIOCHEMISTRY, NEUROMUSCULAR TRANSMISSION, ELECTROCARDIOGRAPHY, RESPIRATION, PHYSIOLOGY.

Distribution Statement : APPROVED FOR PUBLIC RELEASE