Accession Number : AD0474585

Title :   PENTOBARBITAL SODIUM ANESTHESIA IN THE DOG.

Descriptive Note : Interim rept. no. 8,

Corporate Author : NAVAL MEDICAL FIELD RESEARCH LAB CAMP LEJEUNE NC

Personal Author(s) : Gilmore, Joseph P.

Report Date : AUG 1965

Pagination or Media Count : 5

Abstract : Studies have been done in the dog to determine some of the circulatory effects of anesthetic amounts of pentobarbital sodium. The results indicate that (1) except for the initial transient hypotension that occurs on injection of the anesthetic, pentobarbital sodium has little influence on the mean arterial blood pressure of the normotensive dog; (2) cardiac output is unchanged 1 hr following anesthesia, then decreases approximately 25% and remains at this level from the 2nd to at least the 4th hr of anesthesia; (3) estimated hepatic blood flow is not modified by pentobarbital sodium but the spanchnic A-V oxygen difference decreases (4) pentobarbital sodium does not modify arterial oxygen saturation, plasma volume, or red cell mass; (5) the apparent hemodilution of the pentobarbitalized dog appears to result from the splenic sequestration of erythrocytes; (6) the leukopenia which occurs in the dog under pentobarbital sodium also occurs in the splenectomized dog and appears to result at least in part, from the pooling of leukocytes in the pulmonary bed; and (7) the splenic blood of the normal unanesthetized dog does not appear to have a cell-to-plasma ratio different from that of the peripheral blood. (Author)

Descriptors :   (*BARBITURATES, DOGS), ANESTHESIA, CARDIOVASCULAR SYSTEM, BLOOD PRESSURE, SPLEEN, EXCISION, LEUKOCYTES, ERYTHROCYTES, BLOOD DISEASES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE