Accession Number : AD0474987

Title :   THE EFFECT OF COBALT-60 (GAMMA RADIATION) ON THE CENTRAL NERVOUS SYSTEM ELECTROENCEPHALOGRAPHIC AND PATHOLOGICAL STUDIES WITH RECENTLY INTRODUCED TECHNIQUES.

Descriptive Note : Final rept. 4 Aug 64-3 Aug 65,

Corporate Author : YOKOHAMA MUNICIPAL UNIV (JAPAN) FACULTY OF MEDICINE

Personal Author(s) : Tsuya, Akira

Report Date : 23 SEP 1965

Pagination or Media Count : 25

Abstract : The effect of Cobalt-60 gamma radiation on the central nervous system was studied electro encephalographically on the unstrained and unanesthetized rabbits. Spontaneous electrical brain activity has been studied after graded doses of single head irradiation from 15000R to 200R. For eliciting reversible slight changes of EEG pattern (lowering, slowing), relatively small dose between 1000R to 200R was required, although massive irradiation over 5000R is needed to show dominant changes in EEG, as believed generally. Difference in timely change of EEG pattern between forntal cortex and subcortical structures indicates the higher radiosensitivity of reticular formation than other subcortical structures. Electroencephalographic arousal response induced by electrical stimulation of reticular formation showed a transient decrease in threshold, after graded doses of single head irradiation, from 3000R to 100R. By frequency analysis an enhanced condition in these systems was confirmed. Mouse brain was irradiated by X-ray ranging from 700R to 7000R. Fine granular glycogen deposits were found in the neuropil, while there was no evidence of blood brain barrier damage by mean of fluorescein serum protein technique. Predilection site of glycogen accumulation was rhinencephalon and the granules were most prominently observed around necrotic cells in the lamina medullaris. (Author)

Descriptors :   (*CENTRAL NERVOUS SYSTEM, RADIATION EFFECTS), RABBITS, GAMMA RAYS, X RAYS, ELECTROENCEPHALOGRAPHY, BRAIN, RESPONSE, THRESHOLDS(PHYSIOLOGY), MICE, GLYCOGEN, DEPOSITION, RADIATION INJURIES, HEAD(ANATOMY), RADIOACTIVE ISOTOPES, COBALT, ELECTROPHYSIOLOGY, BEHAVIOR, RADIATION DOSAGE, TRACER STUDIES, FLUORESCENCE, PERMEABILITY, CEREBROVASCULAR SYSTEM, PATHOLOGY.

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE