Accession Number : AD0474990

Title :   EPIDEMIOLOGICAL AND GENETICAL STUDY ON THE DRUG-RESISTANCE OF SHIGELLAE AND STAPHYLOCOCCI.

Descriptive Note : Final rept. no. 1, 15 May 64-14 May 65,

Corporate Author : GUNMA UNIV MAEBASHI (JAPAN)

Personal Author(s) : Mitsuhashi, Susumu

Report Date : 14 MAY 1965

Pagination or Media Count : 4

Abstract : The strains of Staphylococcus aureus were collected from the in-patients in the 17 hospitals dispersed geographically in Japan. According to the determination of their drug-resistance and phage typing patterns, it was found that the multiple resistance and restricted phage type were predominant in the epidemic strains of St. aureus. There are two types in the degree of drug-resistance, i.e., high- and meso-resistance and the degree of resistance is extremely high in the multiple resistant strains carrying TC resistance. Three types of the resistance to macrolide antibiotics were presented. By the artificial elimination and transductional analysis, it was concluded that the determinants of penicillinase production and of the resistance to macrolide antibiotics are located together on a single genetic element. (Author)

Descriptors :   (*STAPHYLOCOCCUS AUREUS, EPIDEMIOLOGY), DRUGS, TOLERANCES(PHYSIOLOGY), PENICILLINS, BACTERIOPHAGES, ANTIBIOTICS, RESISTANCE(BIOLOGY), BIOCHEMISTRY.

Subject Categories : Biochemistry
      Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE