Accession Number : AD0475558

Title :   EMPLOYMENT OF CROSS CIRCULATION AND MULTIPLE HEAT EXCHANGERS TO INDUCE DEEP HYPOTHERMIA: ITS USE IN THE STUDY OF CENTRAL NERVOUS SYSTEM CHANGES.

Descriptive Note : Interim technical rept. Sep 63-Sep 64,

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Lesage, Alan M.

Report Date : SEP 1965

Pagination or Media Count : 12

Abstract : These studies have excluded the role of silicone and oxygen bubbles in the genesis of brain and spinal cord damage. The studies confirm the fact that 60 min of circulatory standstill is the upper limit of the tolerable ischemia even at temperatures below 10 C. Spinal cord changes noted in the cross-circulation group were similar to those noted in the bubble oxygenator group. The role of ischemia and hypothermia in the genesis of this lesion is not known. It is thought that the lesion is most likely in the cord, but the possibility of its being in the peripheral nerves has not been excluded. (Author)

Descriptors :   (*CENTRAL NERVOUS SYSTEM, BLOOD CIRCULATION), BLOOD TRANSFUSION, HYPOTHERMIA, HEAT EXCHANGERS, MECHANICAL ORGANS, INHIBITION, PATHOLOGY, BRAIN, SPINAL CORD, PERIPHERAL NERVOUS SYSTEM, HEART.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE