Accession Number : AD0477480

Title :   RESEARCH AND REPORTS ON EFFECTS OF ALCOHOL AND DRUGS ON RATS UNDER AMBIENT AND LOW TEMPERATURES, MEASURED BY AVOIDANCE RESPONSE.

Descriptive Note : Final research rept. 1 May 64-31 May 65,

Corporate Author : HINE LABS INC SAN FRANCISCO CA

Personal Author(s) : Leung, K. C. ; Stone, G. C.

Report Date : 31 MAY 1965

Pagination or Media Count : 71

Abstract : This report summarizes the experimental results obtained in the evaluation of the effects of alcohol and drugs on rats under ambient and low temperatures as measured by avoidance response. Based on LD50 determinations, the toxicity of the tranquilizers, chlorpromazine and chlordiazepoxide, and the sedative hypnotics, morphine and promethazine, increased with acute exposure to cold. The toxicity of amphetamine, a stimulant, was lowered at reduced temperatures. (Author)

Descriptors :   *PSYCHOPHYSIOLOGY), *TOXICITY), (*DRUGS, (*TRANQUILIZERS, ACCLIMATIZATION, ALCOHOLS, COLD WEATHER TESTS, STRESS(PHYSIOLOGY), PSYCHOMOTOR TESTS, CHLORPROMAZINE, RESERPINE, AMPHETAMINES, SHOCK(PATHOLOGY), RATS, RESPONSE, REACTION(PSYCHOLOGY), DOSAGE, PHARMACOLOGY, ANALYSIS OF VARIANCE, MOTIVATION.

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE