Accession Number : AD0482428

Title :   RESEARCH ON TOXICITY CHANGES IN THE CENTRAL NERVOUS SYSTEM. THE RESPONSE OF THE CENTRAL NERVOUS TISSUE TO X-IRRADIATION HISTOLOGICAL AND ELECTRONMICROSCOPICAL INVESTIGATION.

Descriptive Note : Final technical rept.,

Corporate Author : DEUTSCHE FORSCHUNGSANSTALT FUER PSYCHIA- TRIE (MAX-PLANCK-INST) MUNICH (GERMA NY F R)

Personal Author(s) : Scholz, W. ; Hager, H. ; Hirschberger, W. ; Breit, A.

Report Date : 15 MAY 1961

Pagination or Media Count : 69

Abstract : Acute local necroses comprising all tissue elements were produced by single doses of 10 kr or more; delayed lesions preferring the vascular system resulted from single or fractional doses of 5 kr or less. It seems that the fundamental effect of x-irradiation as indicated by a disorder of the blood-brain barrier and by excessive changes in the volume of cellular tissue constituents, is a disturbance of the membrane functions. (Author)

Descriptors :   (*CENTRAL NERVOUS SYSTEM, RADIOBIOLOGY), (*X RAYS, PATHOLOGY), WEST GERMANY, HISTOLOGICAL TECHNIQUES, TOXICITY, DOSE RATE, CEREBELLUM, BRAIN, ERYTHROCYTES, BIOPSY, DOSAGE, CEREBRAL CORTEX, NERVE CELLS, ELECTRON MICROSCOPY, RADIATION INJURIES, RADIATION DOSAGE, HISTOLOGY, HAMSTERS.

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE