Accession Number : AD0482758

Title :   ELECTROCHEMISTRY AND ELECTRON SPIN RESONANCE STUDIES OF THE PYRIDINE ALDOXIMES AND DERIVATIVES. I. POLAROGRAPHY OF THE PAM ISOMERS.

Descriptive Note : Technical rept. Oct 63-Apr 64,

Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s) : Giordano, Wally P. ; Mennitt, P. Gary

Report Date : DEC 1965

Pagination or Media Count : 50

Abstract : The 2, 3, and 4 positional isomers of pyridine aldoxime and 1-methyl pyridinium aldoxime (1-PAM) in dimethyl formamide were examined polarographically. Studies included the effects of concentration, water, acid, and base. Calculations were made of reduction-potential, diffusion-current constant, electrons transferred, shape, slope, and diffusion coefficient. Analysis of the electrochemical-reduction pathways suggested a number of one-electron changes and free-radical intermediates. The use of the electrochemical method of free-radical generation as an adjunct to electron spin-resonance spectroscopy was demonstrated in this study series. The use of the polarographic technique for qualitative and quantitative analyses was established. Electrochemical reduction of each of the above isomers proceeded in at least three steps. The 3 and 4 isomers appeared to have similar pathways, whereas the 2 isomers did not. (Author)

Descriptors :   *CHEMOTHERAPEUTIC AGENTS, *PYRIDINES, *OXIMES, MOLECULAR ISOMERISM, MOLECULAR STRUCTURE, ANTICONVULSANTS, THEORY, REDUCTION, TOXICITY, CHOLINESTERASE INHIBITORS, POLAROGRAPHIC ANALYSIS, ELECTRON PARAMAGNETIC RESONANCE, PH FACTOR, REACTION KINETICS, FREE RADICALS, REDUCTION(CHEMISTRY), CONCENTRATION(CHEMISTRY).

Subject Categories : Pharmacology
      Chemical, Biological and Radiological Warfare
      Atomic and Molecular Physics and Spectroscopy

Distribution Statement : APPROVED FOR PUBLIC RELEASE