Accession Number : AD0482946

Title :   EFFECT OF THE CONTAINER ON THE STABILITY OF AQUEOUS SOLUTIONS OF PRALIDOXIME CHLORIDE.

Descriptive Note : Rept. for Jan 64-Mar 65,

Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s) : May, Jon R. ; Kondritzer, Albert A.

Report Date : DEC 1965

Pagination or Media Count : 19

Abstract : The storage stability of solutions of pralidoxime chloride (2-PAMCl) in metal containers was studied. The metal containers were a component part of the AtroPen Auto-Injector. The oxime was placed in various containers, and its rate of decomposition was observed at ambient temperatures, 40, 65, and 95 C. Results are presented graphically. Decreased stability may be used to catalysis by the metallic surface. It the AtroPen Auto-Injector is to be used for the administration of 2-PAMCl solutions, glass or suitable plastic containers should be used. (Author)

Descriptors :   (*OXIMES, CONTAINERS), (*NERVE AGENTS, CHEMOTHERAPY), STABILITY, GLASS, PLASTICS, STAINLESS STEEL, INJECTIONS(MEDICINE), ATROPINE, CATALYSIS, STORAGE, CHLORIDES, COMPLEX COMPOUNDS.

Subject Categories : Pharmacology
      Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE