Accession Number : AD0487483

Title :   THE PHYSIOLOGICAL EFFECTS OF ARGON, HELIUM AND THE RARE GASES.

Descriptive Note : Technical rept., 1 Jun 65-31 Jul 66,

Corporate Author : UNION CARBIDE CORP TONAWANDA NY LINDE DIV

Personal Author(s) : Schreiner, H. R. ; Bruemmer, J. H. ; Doebbler, G. F.

Report Date : 31 JUL 1966

Pagination or Media Count : 111

Abstract : Information related to the mechanism of inert gas effects on biological systems has been developed in studies on the molecular, cellular and intact animal level. Tyrosinase and lipoxidase are inhibited by helium, neon, argon, krypton, xenon, nitrogen, sulfur hexafluoride and nitrous oxide. Effectiveness of inhibition (1.9% per atm N2O for nitrous oxide) generally increases with increasing solubility of the gas. Acetyl cholinesterase is inhibited by sulfur hexafluoride and nitrous oxide only. A similar inhibitory action of helium group gases, hydrogen, nitrogen and nitrous oxide was observed with epithelial-type (HeLa) and fibroblast-type (L-929), mammalian cells in culture. In inhibitory effectiveness, these gases rank in the following order: He, Ne, N2, H2<Ar <Kr <Xe <N2O. Helium, neon, nitrogen and argon differ in the severity of decompression sickness elicited in small laboratory animals as follows: He, Ne <N2 <Ar. In the rabbit, good correlation was observed between the development of symptoms of decompression sickness and the rise of three selected plasma enzymes (GOT, GPT and LDH). (Author)

Descriptors :   (*RARE GASES, PHYSIOLOGY), (*CONTROLLED ATMOSPHERES, RARE GASES), XENON, ARGON, HELIUM, METABOLISM, IN VITRO ANALYSIS, TISSUE CULTURE CELLS, GROWTH(PHYSIOLOGY), INHIBITION, ENZYME INHIBITORS, ACETYLCHOLINESTERASE, OXIDOREDUCTASES, DECOMPRESSION SICKNESS, BLOOD PLASMA, ENZYMES, NEON, KRYPTON, NITROGEN, NITROGEN COMPOUNDS, OXIDES, IN VIVO ANALYSIS, TYROSINE, LIPIDS, MITOCHONDRIA, CHOLINESTERASE, HYDROGEN.

Subject Categories : Anatomy and Physiology
      Stress Physiology
      Life Support Systems

Distribution Statement : APPROVED FOR PUBLIC RELEASE