Accession Number : AD0488772

Title :   THE DISTRIBUTION AND THE CHEMICAL FORMS OF 2-MERCAPTOETHYLGUANIDINE AND BIS(2-GUANIDOETHYL) DISULFIDE GIVEN ORALLY IN PROTECTIVE DOSES TO MICE.

Descriptive Note : Technical documentary rept.,

Corporate Author : ALBERT EINSTEIN MEDICAL CENTER PHILADELPHIA PA

Personal Author(s) : Kollmann, George ; Shapiro, Bernard ; Schwartz, Emanuel E.

Report Date : JAN 1963

Pagination or Media Count : 6

Abstract : The distribution and chemical forms of 2-mercaptoethylguanidine (MEG) and bis(2-guanidoethyl) disulfide (GED) were studied in the various tissues of 8- to 10-week-old C57B1 male mice 30 minutes after an oral protective dose of 400 mg./kg. of MEG-S(35) and GED-S(35). At 30 minutes after oral administration of MEG or GED, a significant amount of protective agent remained in the gastrointestinal tract. This accounts for some of the differences in LD50/30 values for equal doses of protective agent by oral and intraperitoneal routes. MEG was absorbed from the intestines more rapidly than GED, and protective forms appeared in the tissues in higher concentrations after MEG. This explains the better protection provided by oral MEG as compared with oral GED. The difference in absorption rates of MEG and GED may be useful in controlling the speed of onset and the duration of protection by these agents in mice. (Author)

Descriptors :   *RADIOPROTECTIVE AGENTS), (*GUANIDINES, TISSUES(BIOLOGY), MICE, INTESTINES, DOSAGE, RADIOCHEMISTRY, SULFIDES, LABELED SUBSTANCES, SULFUR, MEASUREMENT, CHROMATOGRAPHIC ANALYSIS, INGESTION(PHYSIOLOGY), INJECTIONS(MEDICINE), STOMACH.

Subject Categories : Anatomy and Physiology
      Radiobiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE