Accession Number : AD0600227

Title :   RESEARCH ON DRUGS ON NEURONAL TRANSMISSION.

Descriptive Note : Final rept.

Corporate Author : LONDON UNIV (ENGLAND)

Personal Author(s) : Quilliam,J. P.

Report Date : JAN 1964

Pagination or Media Count : 88

Abstract : The actions of centrally active drugs and related compounds on transmission across the synapses of the superior cervical ganglion of the cat, rabbit and rat have been studied because these synaptic junctions may be regarded as being closely allied to those seen between central neurones. Experiments on the cat ganglion were made in vivo with repetitive preganglionic nerve stimulation while those on the isolated ganglia of the rabbit and the rat were made in vitro and usually involved the application of single stimuli to the preganglionic trunk with recording of the evoked ganglionic or postganglionic action potentials. The results are summarized in 2 parts firstly, quantitative findings and secondly, qualitative observations with particular reference to modes of action. (Author)

Descriptors :   (*DRUGS, NEUROMUSCULAR TRANSMISSION), (*NEUROMUSCULAR TRANSMISSION, DRUGS), *CNS DEPRESSANTS, CENTRAL NERVOUS SYSTEM, AUTONOMIC NERVOUS SYSTEM, AUTONOMIC AGENTS, CHOLINESTERASE INHIBITORS, LOCAL ANESTHETICS, ACETYLCHOLINE, STIMULATION(PHYSIOLOGY), NERVE CELLS, NERVE FIBERS, ALDEHYDES, BARBITURATES, PENTANOLS, PIPERIDINES

Distribution Statement : APPROVED FOR PUBLIC RELEASE