Accession Number : AD0600228

Title :   SCREENING OF POTENTIAL RADIO-PROTECTIVE COMPOUNDS IN MICE.

Descriptive Note : Annual progress rept., 15 Mar 63-15 Feb 64,

Corporate Author : WOODARD RESEARCH CORP HERNDON VA

Personal Author(s) : Woodard,Geoffrey

Report Date : 12 MAY 1964

Pagination or Media Count : 9

Abstract : A total of 701 coded compounds were screened for their potential radio-protective potency in mice in accordance with the following method: (1) An approximate maximum tolerated dose of each coded test compound was determined by administering the compound intraperitoneally in graded doses to groups of mice and these mice observed for pharmacologic and toxicologic signs. Survivors at seven days were subjected to gross necropsy, also. (2) The test compound at this dose was then administered intraperitoneally to groups of six mice. At an interval when the compound was estimated to be most pharmacologically active, these mice were exposed to radiation from a Maxitron 300 X-ray unit at a dose which was calculated to be the LD 100/30 in similar groups of untreated animals. Untreated animals were exposed to this dose of radiation at the same time thereby serving as controls. The estimated protection offered by administration of the test compound was then determined, as compared with control values, and tabulated. (Author)

Descriptors :   (*RADIOPROTECTIVE AGENTS, TEST METHODS), (*BIOASSAY, RADIOPROTECTIVE AGENTS), DRUGS, DOSAGE, RADIATION DOSAGE, RADIATION EFFECTS, RADIATION SICKNESS, INHIBITION, X RAYS, RADIATION TOLERANCE, TOXICITY, MICE

Distribution Statement : APPROVED FOR PUBLIC RELEASE