Accession Number : AD0600381

Title :   THE EFFECT OF OVARIAN HORMONES ON THE ACTIVITY OF HYPOTHALAMIC NEURONES.

Descriptive Note : Final technical rept.,

Corporate Author : CAMBRIDGE UNIV (ENGLAND)

Personal Author(s) : Cross,B. A. ; Silver,I. A.

Report Date : 24 APR 1964

Pagination or Media Count : 14

Abstract : Unit activity in the diencephalon of adult female rats under light urethane anaesthesia was recorded with steel microelectrodes and a polygraphic recording system. The responsiveness of neurones to pain and cold stimuli on the tail and mechanical probing of the cervix was examined. In dioestrous rats, injection of one or ten micrograms of oestradiol intramuscularly increased the incidence of inhibitory effects of the standard stimuli in hypothalamic neurones while one microgram of oestradiol produced no change. In a group of pseudopregnant rats, hypothalamic neurones showed a markedly depressed responsiveness to cervical probing similar to that previously observed in cyclic rats following injected progesterone. No corresponding hormonally induced changes in responsiveness were observed in thalamic neurones. (Author)

Descriptors :   (*OVARIES, NERVE CELLS), (*ESTROGENS, THALAMUS), (*THALAMUS, ESTROGENS), SEX HORMONES, PROGESTERONE, INHIBITION, STIMULATION(PHYSIOLOGY), PAIN, TEMPERATURE, ELECTROENCEPHALOGRAPHY, RATS

Distribution Statement : APPROVED FOR PUBLIC RELEASE