Accession Number : AD0600549

Title :   VASCULAR RESPONSES DURING HYPOTHERMIA.

Corporate Author : DUKE UNIV DURHAM N C SCHOOL OF MEDICINE

Personal Author(s) : Sealy,W. C. ; Lesage,M. A. ; Young,W. G. ,Jr.

Report Date : OCT 1963

Pagination or Media Count : 30

Abstract : In a series of experiments on dogs, it was found that coreinduced hypothermia of 10 C does cause a decrease in vascular tone. The blood vessels maintain their ability to respond to epinephrine, norepinephrine, acetylcholine, and reflex changes as mediated through the carotid sinus. The response to vagal stimulation was blocked at a somewhat higher temperature than was the response to sympathetic stimulation. The dogs still responded to acetylcholine. Due to causes as yet undetermined, muscle blood flow was greatly diminished during coreinduced hypothermia. This diminution or shift perhaps augments the flow in the central circuit and may be a protective mechanism. Quinidine does not abolish the temperature gradients in muscle. It did reduce the reactivity of the vascular tree, and perhaps in this manner is helpful in maintaining an adequate perfusion of the vital central areas. Abolition of all vascular control, in spite of the attractiveness of the theory of uniform perfusion, may not be advantageous. (Author)

Descriptors :   (*HYPOTHERMIA, BLOOD CIRCULATION), (*BLOOD CIRCULATION, HYPOTHERMIA), MUSCLES, BLOOD PRESSURE, STIMULATION(PHYSIOLOGY), REFLEXES, BODY TEMPERATURE, ACETYLCHOLINE, EPINEPHRINE, DRUGS

Distribution Statement : APPROVED FOR PUBLIC RELEASE