Accession Number : AD0602702

Title :   SYNAPTIC TRANSMISSION IN SYMPATHETIC GANGLIA.

Descriptive Note : Final rept. for 1 Jul 63-30 Jun 64,

Corporate Author : CALIFORNIA UNIV BERKELEY

Personal Author(s) : Libet,Benjamin

Report Date : 15 JUL 1964

Pagination or Media Count : 4

Abstract : The synaptic mechanisms in sympathetic ganglia and the ways in which low doses of atropine may act in the body were investigated. The results obtained support the contention that there is an adrenergic (inhibitory) synaptic mechanism operating in ganglia, in addition to the well known cholinergic one. The activation of this adrenergic mechanism by preganglionic impulses was found to be sensitive to blockade by atropine. Atropine can affect brain function, and has been shown in recent years to block specifically cholinergic effects at certain sites in the brain. Analyses of the effects of cholinergic agents and atropine on brain function should take into account the possibility that these effects are transpiring at postsynaptic sites which generate slow synaptic responses, of the types seen in sympathetic ganglia. (Author)

Descriptors :   (*NEUROMUSCULAR TRANSMISSION, NERVE CELLS), (*GANGLIA, AUTONOMIC NERVOUS SYSTEM), (*ATROPINE, NEUROMUSCULAR TRANSMISSION), DRUGS, ALKALOIDS, BRAIN, AUTONOMIC AGENTS, SYMPATHOMIMETIC AGENTS, PARASYMPATHOLYTIC AGENTS, PSYCHOPHYSIOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE