Accession Number : AD0602965

Title :   FACTORS MODIFYING THE ACTION OF NEUROMUSCULAR BLOCKING AGENTS.

Descriptive Note : Final technical rept. for 1 Apr 63-31 Mar 64,

Corporate Author : ROYAL COLL OF SURGEONS OF ENGLAND LONDON

Personal Author(s) : Payne,J. P.

Report Date : 31 MAR 1964

Pagination or Media Count : 16

Abstract : The effect of the intravenous anaesthetic agents thiopentone and the non-barbiturate preparation 1420 (Bayer) on the response to the neuromuscular blocking agents tubocurarine, gallamine, decamethonium and suxamethonium was tested. The frog rectus and the rat diaphragm-phrenic nerve preparations were used for this purpose. In addition the rat diaphragm preparation was used to investigate the neuromuscular blocking action of these drugs. The neuromuscular blocking properties of another intravenous anaesthetic the eugenol derivative G.34075 and a recently synthesised relaxant diallyl-nortoxiferine were also investigated with this preparation. (Author)

Descriptors :   (*SKELETAL MUSCLE RELAXANTS, BARBITURATES), (*BARBITURATES, SKELETAL MUSCLE RELAXANTS), DRUGS, ANESTHETICS, NEUROMUSCULAR TRANSMISSION, MUSCLE RELAXANTS, CATS, HUMANS, CURARE ALKALOIDS, SUCCINATES

Distribution Statement : APPROVED FOR PUBLIC RELEASE