Accession Number : AD0603452

Title :   STUDIES ON DISTRIBUTION OF ELAPINE VENOMS IN ANIMAL BODIES AFTER ENVENOMATION. A NUCLEOSIDE ISOLATED FROM THE VENOM OF BUNGARUS MULTICINCTUS.

Descriptive Note : Annual progress rept. for Jul 63-Jun 64,

Corporate Author : NATIONAL TAIWAN UNIV TAIPEI

Personal Author(s) : Lee,Chen-Yuan

Report Date : 01 JUL 1964

Pagination or Media Count : 3

Abstract : The distribution of the venom of Bungarus multicinctus, its neurotoxins alpha-and beta-Bungarotoxin) and the venom of Naja naja atra in animal bodies after envenomation was studied. In rabbits injected with the I131-labelled Bungarusvenon, alpha-and beta-Bungarotoxins, and cobra venom respectively at a dose of 1 mg/kg, radioactivity could be detected in the C.S.F. at 15 min. after injection. However, the C.S.F. levels are too low to account for the rapid respiratory paralysis caused by these venoms. Evidence that the radioiodinated venom may undergo decomposition in the animal body is presented. The highest radioactivity was found in kidneys, followed respectively by lungs, spleen, heart, stomach, intestines, diaphragm and skeletal muscle, with the lowest in the brain, which is less than 1/100 of that in kidneys. The distribution patterns of the venoms given subcutaneously in mice were similar to those in rabbits except that relatively higher radioactivity was found in the G-I tract. It is concluded that the neurotoxins of elapid venoms pass the blood-brain barrier with difficulty and that the small amount of the venom detected in the C.S.F. will hardly account for the rapid paralysis of the respiratory center. (Author)

Descriptors :   (*RESPIRATION, VENOMS), (*VENOMS, NUCLEOSIDES), (*PARALYSIS, VENOMS), TOXIC TOLERANCES, RADIOACTIVE ISOTOPES, LABELED SUBSTANCES, PATHOLOGY TISSUES (BIOLOGY), REPTILES, LABORATORY ANIMALS, INJECTION (MEDICINE), CENTRAL NERVOUS SYSTEM, CHINA

Distribution Statement : APPROVED FOR PUBLIC RELEASE