Accession Number : AD0611502

Title :   SOME BIOCHEMICAL EFFECTS OF BETA-MERCAPTOETHANOL ON THE LIVER OF MICE AND RATS (QUELQUES EFFETS BIOCHIMIQUES DU BETA-MERCAPTOETHANOL SUR LE FOIE DE SOURIS ET DE RAT),

Corporate Author : BRUSSELS UNIV (BELGIUM)

Personal Author(s) : Brachet,J. ; Cape,M. ; Decroly,M. ; Six,N.

Report Date : 20 JAN 1961

Pagination or Media Count : 10

Abstract : The effects of beta-mercaptoethanol (HSCH2-CH2OH) on the biochemistry of mouse and rat liver were studied both in vivo and in vitro. The intra-peritoneal injection of mercaptoethanol has no appreciable effect on the soluble -SH, ATP, DNA, and RNA content of the cells. Mercaptoethanol exerts a very definite inhibitory effect on the incorporation of labeled amino acids into liver proteins both in vivo and in vitro (30-40% inhibition). Mercaptoethanol, if injected in vivo, does not set free one of the enzymes characteristic of lysosomes, acid phosphatase; there is no liberation of acid phosphatase when a particulate fraction containing the lysosomes is treated by mercaptoethanol in vitro. (Author)

Descriptors :   (*THIOLS, BIOCHEMISTRY), (*LIVER, THIOLS), (*AMINO ACIDS, INHIBITION), ALCOHOLS, ORGANIC SULFUR COMPOUNDS, ADENOSINE PHOSPHATES, DEOXYRIBONUCLEIC ACIDS, RIBONUCLEIC ACIDS, PROTEINS, ENZYMES, LABELED SUBSTANCES, MICE, RATS, BELGIUM

Distribution Statement : APPROVED FOR PUBLIC RELEASE