Accession Number : AD0612163

Title :   MOLECULAR MECHANISMS OF ANTIMICROBIAL ACTION,

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Personal Author(s) : Hahn,Fred E.

Report Date : 1964

Pagination or Media Count : 15

Abstract : Antibiotics have been found to inhibit (1) cellwall synthesis (penicillin), (2) protein synthesis (chloramphenicol, tetracyclines, streptomycin, erythromycin), (3) RNA synthesis, and (4) DNA synthesis. Mechanisms by which these effects are produced have been studied and typical results of this research are reported. Chloramphenicol and erythromycin appear to inhibit protein biosynthesis by direct interaction with ribosomes. In all instances, the antimicrobial actions occurred in the general area of macromolecular biosynthesis and assemblage.

Descriptors :   (*CHEMOTHERAPEUTIC AGENTS, INFECTIOUS DISEASES), MILITARY MEDICINE, COMMUNICABLE DISEASES, DRUGS, ANTIBIOTICS, PENICILLINS, MOLECULAR PROPERTIES, BIOSYNTHESIS, INHIBITION, PROTEINS, SYNTHESIS, RIBONUCLEIC ACIDS, DEOXYRIBONUCLEIC ACIDS, RIBOSOMES, BACTERIA

Distribution Statement : APPROVED FOR PUBLIC RELEASE