Accession Number : AD0613108

Title :   ACUTE TOXICITY STUDIES ON ETHANOL, PROPANOL, AND BUTANOL,

Corporate Author : TORONTO UNIV (ONTARIO)

Personal Author(s) : MacGregor,D. C. ; Schonbaum,E. ; Bigelow,W. G.

Report Date : 27 APR 1964

Pagination or Media Count : 8

Abstract : Three series of 10 dogs each were used to study the effects of intravenously administered ethanol, propanol-1, and butanol-1. In normothermic dogs, with supported respiration and nitrous oxide anaesthesia (after induction), the mean lethal doses for ethanol, propanol-1, and butanol-1 were 4.90, 2.42, and 1.26 g/kg respectively. At a constant infusion rate, the blood alcohol levels increased almost linearly with time. Relationships between ethanol, propanol-1, and butanol-1 blood levels and blood pressure, pulse, and electrocardiogram were established. Two minutes cardiac standstill occurred at the following blood levels: ethanol, 1499 mg/100 ml; propanol-1, 713 mg/100 ml; butanol-1, 279 mg/100 ml. (Author)

Descriptors :   (*TOXICITY, ALCOHOLS), (*ALCOHOLS, TOXICITY), PROPANOLS, BUTANOLS, PARENTERAL INFUSIONS, DOSAGE, BLOOD ANALYSIS, BLOOD PRESSURE, PULSE RATE, ELECTROCARDIOGRAPHY, TOXIC TOLERANCES, TABLES(DATA), DOGS, CANADA

Distribution Statement : APPROVED FOR PUBLIC RELEASE