Accession Number : AD0614403

Title :   THE INFLUENCE OF CERTAIN PHARMACOLOGICAL PREPARATIONS ON THE BIOELECTRIC ACTIVITY OF THE BRAIN IN SCHIZOPHRENIA,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Gamburg,A. L. ; Denisova,A. M.

Report Date : 20 APR 1965

Pagination or Media Count : 18

Abstract : Utilizing 51 schizophrenic patients and 9 normal subjects, studies were conducted on modifications of the bioelectric activity of the brain in the course of pharmacological tests. By means of EEG indications, some troubles of basic activity were proved with certain patients, and also the character of response to doses of extraordinary excitants. Modifications of biopotentials after the injection of adrenalin, acetylcholine or atropine into the patients were very different than those observed with the normal subjects. At the same time, adrenalin and atropine as well as corticotropine, cortisone, desoicortisone or thyreoidine, eliminate in a selective manner, certain pathological elements of the EEG in certain forms of schizophrenia. Acetylcholine caused evident pathological modifications in the EEG. Once such effect of the medications used has been partially explained by their influence on the adrenergic and cholinergic systems. The results of the research, according to the authors, can facilitate the analysis of pathogenic mechanisms and the research for means of normalization of the reaction of cerebral structures in schizophrenia. (Author)

Descriptors :   (*PHARMACOLOGY, MENTAL DISORDERS), (*MENTAL DISORDERS, PHARMACOLOGY), (*PSYCHOTROPIC AGENTS, ELECTROENCEPHALOGRAPHY), BRAIN, PSYCHIATRY, DRUGS, EPINEPHRINE, ACETYLCHOLINE, ATROPINE, DOSAGE, ADRENOCORTICOTROPIC HORMONE, CORTICOSTEROID AGENTS, AUTONOMIC NERVOUS SYSTEM, CENTRAL NERVOUS SYSTEM, PATHOLOGY, USSR

Distribution Statement : APPROVED FOR PUBLIC RELEASE