Accession Number : AD0615672

Title :   PLASMA ALBUMIN AS AN ACCEPTOR OF FREE FATTY ACIDS,

Corporate Author : TORONTO UNIV (ONTARIO)

Personal Author(s) : Campbell,James ; Martucci,A. D. ; Green,G. R.

Report Date : 30 JAN 1964

Pagination or Media Count : 7

Abstract : Plasma albumin was more effective in solubilizing oleate in an aqueous medium than any of five other proteins or dextran. The solubilizing effect occurred up to an oleate:plasma albumin molar ratio of 7.4, or a total free fatty acids:plasma albumin molar ratio of 7.8. Fraction V (albumin), and to a smaller extent fractions IV sub 1 and IV sub 4 of human plasma, permitted the transfer of free fatty acids from adipose tissue in vitro to the medium, but casein, fibrinogen, fraction II of plasma, egg albumin, gelatin, peptone and dextran did not. Corticotrophin increased the concentration of free fatty acids in the incubated tissue, but their release was dependent on the presence of plasma fractions V, IV sub 1 or IV sub 4. Increasing concentrations of plasma albumin in the medium increased the output of free fatty acids from adipose tissue in vitro, decreased the accumulation of free fatty acids in the tissue and increased the total amount of free fatty acids in tissue plus medium. It is concluded that the release of free fatty acids from adipose tissue a substance with special properties as an acceptor of fatty acids is an absolute requirement, and that plasma albumin performs this function most effectively. (Author)

Descriptors :   (*SERUM ALBUMIN, FATTY ACIDS), (*FATTY ACIDS, SERUM ALBUMIN), ADIPOSE TISSUE, CASEIN, FIBRINOGEN, ALBUMINS, GELATINS, PEPTONES, DEXTRAN, ADRENOCORTICOTROPIC HORMONE, CANADA

Distribution Statement : APPROVED FOR PUBLIC RELEASE