Accession Number : AD0616933

Title :   INTERRELATIONSHIP OF KETONE BODY METABOLISM AND GLUCOSE UTILIZATION BY ADIPOSE TISSUE IN VITRO,

Corporate Author : ARMY MEDICAL RESEARCH AND NUTRITION LAB DENVER COLO

Personal Author(s) : Hanson,Richard W.

Report Date : 14 AUG 1964

Pagination or Media Count : 6

Abstract : The oxidation of acetoacetate-3-C14 by mouse epididymal fat pads and its effect on the pattern of glucose metabolism was studied. Glucose and insulin did not change the rate of acetoacetate oxidation, but the ketone body in the presence of insulin altered the pattern of glucose utilization. Carbon dioxide output, and fatty acid and glycogen synthesis were enhanced, while glyceride-glycerol formation was decreased. This reduced glyceride-glycerol synthesis was reflected in lowered triglyceride synthesis from palmitate. C-1/C-6 ratio experiments showed acetoacetate to increase C14O2 production from glucose-1-C14 in the presence of insulin, suggesting a stimulation of pentose pathway activity. (Author)

Descriptors :   (*KETONES, METABOLISM), (*GLUCOSE, METABOLISM), ADIPOSE TISSUE, OXIDATION, ACETATES, INSULIN, CARBON DIOXIDE, FATS, FATTY ACIDS, GLYCOGEN, PENTOSES, SYNTHESIS, MICE

Distribution Statement : APPROVED FOR PUBLIC RELEASE