Accession Number : AD0617366

Title :   ACUTE TOXICITY IN RATS AND RABBITS,

Corporate Author : AMERICAN OIL CO WHITING IND

Report Date : 25 JUN 1965

Pagination or Media Count : 16

Abstract : Compound LF-4713 was administered orally to albino rats at dosage levels extending from 250 to 10,000 mg./kg. Pharmacodynamic and/or toxic signs were essentially absent at dosage levels through 5000 mg./kg. At 10,000 mg./kg. hypoactivity, ataxia, nasal and oral porphyrin discharge and flaccidity were observed over a 48-hour period. Three-of-five rats died within 48 hours at this dosage level. The acute oral LD50 value was 9260 (6360-13,500) mg./kg. In primary skin and dermal LD50 studies in rabbits, LF-4713 was found to be devoid of irritating properties. No pharmacotoxic signs or mortalities were observed in either experiment. Instillation of LF-4713 into the eye of albino rabbits produced a mild conjunctivitis of 48-hour duration. The results of this test indicate that LF-4713 is not an irritant to the eye mucosa of the rabbit. (Author)

Descriptors :   (*HYDRAULIC FLUIDS, TOXICITY), (*TOXICITY, HYDRAULIC FLUIDS), DOSAGE, SKIN(ANATOMY), EYE, DISEASES, PATHOLOGY, RATS, RABBITS, DOGS, TEST METHODS

Distribution Statement : APPROVED FOR PUBLIC RELEASE