Accession Number : AD0617755

Title :   EVALUATION OF SOME ANTIMOTION SICKNESS DRUGS ON THE SLOW ROTATION ROOM (NO. 1),

Corporate Author : NAVAL SCHOOL OF AVIATION MEDICINE PENSACOLA FLA

Personal Author(s) : Wood,Charles D. ; Graybiel,Ashton ; mcDonough,Robert G. ; Kennedy,Robert S.

Report Date : 29 MAR 1965

Pagination or Media Count : 14

Abstract : A series of antimotion sickness drugs was evaluated on the human centrifuge at the Navy School of Aviation Medicine. The procedures used enabled the same stimulus to be applied to the individual subjects through the series of drug tests. A combination of hyoscine and d-amphetamine was found to be the most effective preparation. Hyoscine alone was the most effective single drug followed by d-amphetamine and meclizine Prochlorperazine was slightly effective, but chlorpromazine, thiethylperazine, and trimethobenzamide were ineffective. Hyoscine alone produced pronounced drowsiness. The combination with d-amphetamine relieved this side effect but not the vertigo and dry mouth. The advantages of the human centrifuge in the testing of antimotion sickness drugs are pointed out. (Author)

Descriptors :   (*MOTION SICKNESS, DRUGS), PHARMACOLOGY, ROTATION, ACCELERATION TOLERANCE, STRESS(PHYSIOLOGY), SCOPOLAMINE, AMPHETAMINES, CHLORPROMAZINE, VERTIGO, CENTRIFUGES, HUMANS, AVIATION MEDICINE

Distribution Statement : APPROVED FOR PUBLIC RELEASE