Accession Number : AD0617823

Title :   CHEMOTHERAPY WITH BITHIONOL-S-OXIDE IN ANIMALS INFECTED WITH PARAGONIMUS WESTERMANI.

Descriptive Note : Research rept.,

Corporate Author : NAVAL MEDICAL RESEARCH UNIT NO 2 TAIPEI (TAIWAN)

Personal Author(s) : Kim,Dong Chan ; Sun,Shih Chien ; Bergner,John F.,Jr.

Report Date : 1963

Pagination or Media Count : 15

Abstract : Bithionol-S-oxide (Bitin-S) was found to be effective against paragonimiasis in animals infected with Paragonimus westermani. Bitin-S 100mg/kg. body weight was administered every other day or daily for varying periods to cats, dogs and a monkey infected with P. westermani. Efficacy of the agent against paragonimiasis varied depending on host species and on the magnitude of the infection. Paragonimus infection in cats required more prolonged doses than in dogs or monkey; and the heavyinfected animals needed more prolonged treatment than those in light-infected animals. Cats and monkey tolerated the agent 100mg/kg administered every other day for 10 to 12 times and even to the additional 50mg/kg administered daily for 35 times in cats. Dogs were very sensitive to the agent with the doses 100mg/kg. every other day or 50mg/kg daily administration, showing vomiting, diarrhea, loss of appetite, and loss of body weight. However, no toxic manifestations were found in histo-pathological studies with the above used doses. (Author)

Descriptors :   (*TREMATODES, CHEMOTHERAPY), (*PARASITIC DISEASES, CHEMOTHERAPEUTIC AGENTS), (*CHEMOTHERAPEUTIC AGENTS, PARASITIC DISEASES), EGGS, MORPHOLOGY(BIOLOGY), DOSAGE, MEDICAL EXAMINATION, HISTOLOGY, PATHOLOGY, DOGS, CATS, MONKEYS, TAIWAN

Distribution Statement : APPROVED FOR PUBLIC RELEASE