Accession Number : AD0617979

Title :   PROPOSED MODE OF ACTION OF CORTICOSTEROIDS ON THE CONNECTIVE TISSUE,

Corporate Author : CHILDREN'S HOSPITAL WASHINGTON D C BIOCHEMICAL RESEARCH LAB

Personal Author(s) : Houck,J. C. ; Patel,Y. M.

Report Date : 1965

Pagination or Media Count : 8

Abstract : Previously reported changes in dermal chemistry associated with cortisol administration are explained on the basis of: (1) a hormonally potentiated release of a cellular protease into the extracellular compartment of the connective tissue; (2) the limited proteolytic activation of collagenase zymogen by this protease; and (3) the digestion of insoluble collagen by the activated dermal collagenase. The dermal chemical responses of rats to cortisol were inhibited by 'Dilantin' and by age, as was the ability of the steroid to effect the release of cellular protease into the ground substance.

Descriptors :   (*CORTICOSTEROID AGENTS, CONNECTIVE TISSUE), (*CONNECTIVE TISSUE, CORTICOSTEROID AGENTS), SKIN(ANATOMY), COLLAGEN, ENZYMES, PEPTIDE HYDROLASES, STEROIDS, RIBONUCLEIC ACIDS, CYTOPLASM, AGING(PHYSIOLOGY), RATS

Distribution Statement : APPROVED FOR PUBLIC RELEASE