Accession Number : AD0618109

Title :   INTERACTION BETWEEN PENTOBARBITAL AND DECREASED CALCIUM ION ON GUINEA PIG ATRIA,

Corporate Author : STANFORD MEDICAL CENTER PALO ALTO CALIF

Personal Author(s) : Smith,N. Ty ; Corbascio,Aldo N.

Report Date : 1964

Pagination or Media Count : 16

Abstract : By the method of isobolographic projection, the interaction of pentobarbital and decreased calcium ion was studied on the isometric and isotonic contrations of ten electrically driven or spontaneously beating guinea pig atria. Synergism (potentiation) was present at all effect levels with all parameters in electrically driven atria. In spontaneously beating atria, the synergism present at lower levels shifted to antagonism at higher effect levels. In describing the interaction between two drugs, the investigator must define the effect level. The mechanism of this synergistic interaction is probably the postulated action of calcium and pentobarbital on the same membrane sites, plus a possible chelation of calcium by anesthetic agents. The results suggest that some anesthetic agents may considerably modify the circulatory effects of rapid, massive blood transfusions. (Author)

Descriptors :   (*BARBITURATES, CALCIUM), (*ANESTHETICS, BLOOD CIRCULATION), HEART, PATHOLOGY, IONS, DRUGS, BLOOD TRANSFUSION, MEMBRANES(BIOLOGY), GUINEA PIGS

Distribution Statement : APPROVED FOR PUBLIC RELEASE