Accession Number : AD0618510

Title :   STUDIES OF THE RENAL CONCENTRATING MECHANISM IN HUMANS. I. THE EFFECT OF HYPERTHYROIDISM,

Corporate Author : WASHINGTON UNIV SEATTLE

Personal Author(s) : Cutler,R. E. ; Glatte,H. ; Dowling,J. T.

Report Date : 1964

Pagination or Media Count : 13

Abstract : Summary: (1) The maximum urinary osmolality after dehydration and exogenous vasopressin was significantly decreased during thyrotoxicosis in patients and during the administration of 1-triiodothyronine to normal subjects when compared to their eumetabolic state. Although Umax was decreased during thyrotoxicosis, TcH2O during a moderate mannitol diuresis was unchanged in most patients. The data suggest that the decreased Umax and normal TcH2O in thyrotoxic individuals is probably caused by an increase in medullary blood flow with a decrease in medullary osmolality. (2) Renal hemodynamics were universally increased during induced thyrotoxicosis in normals but were not significantly changed in patients with thyrotoxicosis. (3) Urea clearance during mannitol diuresis paralleled the changes in GFR in both groups. It is possible that the decrease in plasma urea noted in thyrotoxic patients is due to decreased hepatic synthesis. (Author)

Descriptors :   (*THYROID GLAND, DISEASES), (*URINARY SYSTEM, THYROXINE), (*THYROXINE, URINARY SYSTEM), THYROID HORMONES, TOXICITY, PITUITARY HORMONES, URINE, UREA, EXCRETION, KIDNEYS, DIURETICS, BLOOD VOLUME

Distribution Statement : APPROVED FOR PUBLIC RELEASE