Accession Number : AD0618755

Title :   PHYSICAL AND CHEMICAL CHARACTERISTICS OF HIGH PH INTRALIPID FAT EMULSIONS.

Descriptive Note : Rept. for 1 Nov 64-1 Jul 65,

Corporate Author : APPLIED SCIENCE LABS INC STATE COLLEGE PA

Personal Author(s) : Pelick,Nicholas ; Tinker,John H. ; Steim,Joseph M.

Report Date : 01 JUL 1965

Pagination or Media Count : 18

Abstract : Intralipid intravenous fat emulsions, that were purposely prepared to have high pH, were broken down into oil and water phases. The neutral and polar lipids and water soluble materials were examined by chromatographic procedures. Extreme differences were found in two different bottles from the same batch. Products of hydrolysis such as free fatty acids, lysolipids, free glycerol, alpha-glycerol phosphate and amino acids were detected. All of the analytical work was done using various thin-layer and paper chromatographic methods. Identifications were made with authentic standards and colorimetric chromogenic reagents. Rapid changes in pH were shown to occur as time passed. (Author)

Descriptors :   (*PARENTERAL INFUSIONS, LIPIDS), (*FATS, COLLOIDS), (*LIPIDS, PH FACTOR), BLOOD SERUM, OILS, CHROMATOGRAPHIC ANALYSIS, HYDROLYSIS, FATTY ACIDS, ALCOHOLS, ORGANIC PHOSPHORUS COMPOUNDS, AMINO ACIDS, COLORIMETRIC ANALYSIS, PHYSICAL PROPERTIES, CHEMICAL PROPERTIES

Distribution Statement : APPROVED FOR PUBLIC RELEASE