Accession Number : AD0619120

Title :   DIALYSIS FOR INTOXICATION WITH LIPID SOLUBLE DRUGS: ENHANCEMENT OF GLUTETHIMIDE EXTRACTION WITH LIPID DIALYSATE,

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Personal Author(s) : Shinaberger,James H. ; Shear,Leroy ; Clayton,Lloyd E. ; Barry,Kevin G. ; Knowlton,Marjorie

Report Date : 1965

Pagination or Media Count : 5

Abstract : These in vivo studies demonstrate that the removal of glutethimide during dialysis is significantly increased when lipid is substituted for the usual aqueous dialysis solution. The very low water solubility of many lipid soluble compounds probably limits their removal by routine dialysis methods. Their high lipid solubility not only permits relatively small volumes of lipid dialysate to contain large amounts of these drugs, but also prevents back diffusion after they have crossed a semipermeable membrane from an aqueous into a lipid phase. This maintains a maximum effective diffusion gradient, resulting in an increased rate of net transfer across the membrane. Concentration ratios during peritoneal dialysis with lipid increased more rapidly than during hemodialysis. This suggests that glutethimide diffuses through the lipid-containing cells of the peritoneum more readily than it does through the cellulose dialyzer membrane. Peritoneal dialysis with lipid emulsion regularly produced visible lipemia which was associated with a slight increase in blood glutethimide concentration. This suggests that glutethimide was extracted from tissue depots into the lipemic plasma. The long-term effects of intraperitoneal lipid emulsion infusion have not been adequately studied, and clinical use of peritoneal dialysis with lipid must await further animal tolerance studies. (Author)

Descriptors :   (*HYPNOTICS AND SEDATIVES, SEMIPERMEABILITY), ANESTHETICS, PHARMACOLOGY, LIPIDS, SOLUBILITY, PARENTERAL INFUSIONS, PERITONEUM, MEMBRANES(BIOLOGY), BLOOD CHEMISTRY, COLLOIDS, DIFFUSION, TOXIC TOLERANCES, DOGS

Distribution Statement : APPROVED FOR PUBLIC RELEASE