Accession Number : AD0619415

Title :   CURRENT CONCEPTS OF ACUTE CARBON TETRACHLORIDE HEPATOTOXICITY,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : ANDREWS,Philip W.

Report Date : FEB 1963

Pagination or Media Count : 30

Abstract : A literature survey of hydrocarbon-induced, experimental, acute hepatotoxicity was made. It was concluded that carbon tetrachloride, and probably other hydrocarbons, directly interfere with the selective permeability of the liver cell wall and membranous endoplasmic reticulum for electrolytes, water, and certain hydrophilic proteins. Concomitantly the toxin stimulates the sympathetic nervous system and the release of its hormones. These reduce hepatic blood flow, by vasoconstriction, thereby inducing centrilobular hypoxia, degeneration, and necrosis. These also cause massive mobilization of fats from the peripheral depots. These fats accumulate in the liver where their secretion, as triglycerides, is blocked by unknown mechanisms. (Author)

Descriptors :   (*CARBON TETRACHLORIDE, TOXICITY), (*TOXICITY, LIVER), POISONING, HYDROCARBONS, PERMEABILITY, CELL WALL, ELECTROLYTES(PHYSIOLOGY), CENTRAL NERVOUS SYSTEM, AUTONOMIC NERVOUS SYSTEM, HYPOXIA, NECROSIS, FATS, HORMONES, PATHOLOGY

Distribution Statement : APPROVED FOR PUBLIC RELEASE