Accession Number : AD0619565

Title :   SYNTHESIS OF CERTAIN PHYSIOLOGICALLY ACTIVE PHOSPHORO-ORGANIC COMPOUNDS,

Corporate Author : FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s) : Kabachnik,M. I. ; Godovikov,N. N. ; Godyna,E. I.

Report Date : 06 FEB 1964

Pagination or Media Count : 14

Abstract : There were synthesized a series of O-ethyl-S(ethylmercaptoalkyl)-methylthiophosphinates and also Oethyl-O-(beta-ethylmercaptoethyl)-methylphosphinate and O-ethyl-O-(beta-ethylmercaptoethyl)-chloromethylphosphinate which were converted into the corresponding methylsulfomethylates. There were synthesized O-ethylO-(beta-ethylmercaptoethyl)-beta-dimethylaminoalkylphosphinates from which there were obtained the corresponding N-methylsulfomethylates. It was shown that in the action of an equimolecular quantity of dimethylsulfate on O-ethyl-(beta-ethylmercaptoethyl)-dimethylaminoalkylphosphinate there occurs alkylation with the formation of N-methylsulfomethylates, but not S-methylsulfomethylates. (Author)

Descriptors :   (*CHOLINESTERASE INHIBITORS, SYNTHESIS(CHEMISTRY)), (*ORGANIC SULFUR COMPOUNDS, SYNTHESIS(CHEMISTRY)), ORGANIC SULFUR COMPOUNDS, AMINES, CHLORINE COMPOUNDS, ESTERS, MOLECULAR STRUCTURE, USSR

Distribution Statement : APPROVED FOR PUBLIC RELEASE