Accession Number : AD0619809

Title :   FREE 17-HYDROXYCORTICOSTERIOD CONCENTRATION OF PAROTID FLUID FOLLOWING INTRAVENOUS ADMINISTRATION OF CORTISOL,

Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s) : Shannon,Ira L. ; Katz,Fred H.

Report Date : 1964

Pagination or Media Count : 7

Abstract : In an attempt to determine the time required for adrenocortical steroids to pass from the bloodstream to parotid fluid, twenty subjects were given intravenous injections of cortisol and parotid fluid was collected continuously for 120 minutes after injection. Additional studies were carried out with intramuscular injections and oral administration of cortisol. The parotid fluid free 17-OHCS mean rose from 3.51 (S.D. = 1.57) to 21.34 (S.D. = 4.10) micrograms per 100 ml. in the sample collected during the 20 minutes immediately following intravenous dosage. For each participant, the increase over this interval was highly significant. This very rapid reflection of blood steroid change strengthens the premise that parotid fluid free 17-OHCS measurements may be substituted for blood determinations. (Author)

Descriptors :   (*CORTICOSTEROID AGENTS, SALIVA), (*SALIVA, CORTICOSTEROID AGENTS), PARENTERAL INFUSIONS, SALIVARY GLANDS, STEROIDS, DOSAGE, BLOOD CHEMISTRY, DENTISTRY

Distribution Statement : APPROVED FOR PUBLIC RELEASE