Accession Number : AD0620403

Title :   THE INFLUENCE OF CHRONIC ACCELERATION ON THE EFFECTS OF WHOLE-BODY IRRADIATION IN RATS.

Descriptive Note : Doctoral thesis,

Corporate Author : CALIFORNIA UNIV DAVIS

Personal Author(s) : Casey,Harold Wilton

Report Date : 1965

Pagination or Media Count : 77

Abstract : The following conclusions are drawn from the results of the studies combining acute whole-body irradiation and acceleration. Rats survive and physiologically adapt to 3.0 G chronic acceleration. A reduced body mass and depletion of body fat deposits are the only detectable changes from normal rats. Acceleration following exposures to acute whole-body irradiation, with doses in the mid-lethal range, increases radiation mortality. The mortality increases progressively with accelerative forces of 2.0 and 3.0 G. Prior adaptation to acceleration does not influence the increased radiation mortality. The detrimental effects of acceleration are operative only during the first week following irradiation. Pathological lesions in rats dying or sacrificed following acceleration and irradiation are typical of those produced by irradiation and are not modified by acceleration. Deceleration to normal gravity followed by irradiation does not influence the effects produced by radiation. (Author)

Descriptors :   (*RADIATION EFFECTS, ACCELERATION), (*ACCELERATION, RADIATION EFFECTS), WHOLE BODY IRRADIATION, ADAPTATION(PHYSIOLOGY), STRESS(PHYSIOLOGY), LETHAL DOSAGE, SUBLETHAL DOSAGE, PATHOLOGY, HISTOLOGY, NECROSIS, NEOPLASMS, METABOLISM, RATS, MICE, HAMSTERS, CHICKENS

Distribution Statement : APPROVED FOR PUBLIC RELEASE