Accession Number : AD0620781

Title :   PECULARITIES OF OVINE CELLS IN CULTURE,

Corporate Author : CALIFORNIA UNIV OAKLAND NAVAL BIOLOGICAL LAB

Personal Author(s) : Nelson-Rees,Walter A. ; Kniazeff,Alexis J. ; Darby,Norman B. ,Jr.

Report Date : 27 AUG 1964

Pagination or Media Count : 12

Abstract : The chromosome complement of two ovine (Ovis aries L.) kidney cell lines are described. Nuclei of MDOK, the older cell line, are generally larger than those of OK cells, they are hypo-tetraploid and show considerable chromosomal irregularities both in structure and behavior. The OK line observed since its initiation, is now hyper-diploid and exhibits a gradual accumulation of chromosomes. Both cell lines have in common the fact that they now maintain a larger proportion of chromosomes with interstitial centromeres than telocentric chromosomes. This observation parallels similar ones made earlier in bovine cells. However, the processes whereby this condition arose in the respective cultures are believed to be different and are discussed. (Author)

Descriptors :   (*TISSUE CULTURE CELLS, MAMMALS), (*CHROMOSOMES, TISSUE CULTURE CELLS), (*MAMMALS, CHROMOSOMES), KIDNEYS, CELLS(BIOLOGY), GENETICS, SEX, BOVINES

Distribution Statement : APPROVED FOR PUBLIC RELEASE