Accession Number : AD0622122

Title :   THE EFFECT OF AMINO-OXYACETIC ACID AND HYDROXYLAMINE ON RATS BREATHING OXYGEN AT HIGH PRESSURE,

Corporate Author : DEFENCE RESEARCH MEDICAL LABS TORONTO (ONTARIO)

Personal Author(s) : Wood,J. D. ; Watson,W. J.

Report Date : 09 SEP 1964

Pagination or Media Count : 8

Abstract : The effect of intraperitoneal administration of aminooxyacetic acid and hydroxylamine on oxygen poisoning in rats, as measured by convulsions and deaths, was investigated. Amino-oxygacetic acid was without effect on the number of rats convulsing or dying from exposure to hyperbaric oxygen, although in some cases the number of animals severely convulsing was decreased. Hydroxylamine influenced the degree of oxygen poisoning, the direction of the change depending on the time between administration of the compound and the exposure of the animal. When the time interval was 5 min hydroxylamine enhanced oxygen poisoning, but when the interval was 60 min the amine reduced the toxic effects of oxygen at high pressure. This protection was maximal in the animals which had convulsed following the administration of hydroxylamine before being exposed to hyperbaric oxygen. The significance of the present findings is discussed with respect to theories put forward to account for oxygen poisoning. (Author)

Descriptors :   (*TOXICITY, OXYGEN), (*OXYGEN, POISONING), CONVULSIVE DISORDERS, CENTRAL NERVOUS SYSTEM, AMINO ACIDS, OXYGEN CONSUMPTION, PRESSURE BREATHING, BAROMETRIC PRESSURE, AMINES, RATS, CANADA

Distribution Statement : APPROVED FOR PUBLIC RELEASE