Accession Number : AD0622154

Title :   THE CEREBRAL CIRCULATION AND METABOLISM IN CHRONIC PULMONARY EMPHYSEMA WITH OBSERVATIONS ON THE EFFECTS OF INHALATION OF OXYGEN.

Descriptive Note : Joint research rept.,

Corporate Author : EMORY UNIV ATLANTA GA

Personal Author(s) : Patterson,John L. ,Jr. ; Heyman,Albert ; Duke,T. Whatley

Report Date : 26 JUL 1951

Pagination or Media Count : 13

Abstract : The cerebral blood flow (CBF), oxygen consumption (CMRO2) and vascular resistance (CVR) were determined by the nitrous oxide technique before and during the administration of 85-100% oxygen in nine patients with chronic pulmonary emphysema and in eight control subjects. In the patients with emphysema the mean CBF was significantly elevated, while the mean CMRO2 was slightly below control values. There was a tendency for the emphysematous patients with the lowest arterial pO2 and the highest pCO2 values to show the highest blood flow values. The converse was also true. Inhalation of 85-100% oxygen was generally followed by an increase in CBF in the patients with emphysema in contrast to the control patients in whom the CBF decreased. Two emphysematous patients who had the lowest CBF values while breathing air showed a decrease in CBF during inhalation of oxygen. The mean CMRO2 did not change in either group of patients with oxygen administration. One patient with emphysema exhibited mental aberrations which may have been aggravated by oxygen therapy. Oxygen caused an increase in spinal fluid pressures in the patients with emphysema and either no change or a fall in spinal fluid pressures in the control subjects. (Author)

Descriptors :   (*OXYGEN CONSUMPTION, RESPIRATORY DISEASES), (*BRAIN, RESPIRATORY DISEASES), (*RESPIRATORY DISEASES, BLOOD CIRCULATION), METABOLISM, CEREBRAL CORTEX, RESPIRATION, BLOOD VESSELS, CARBON DIOXIDE

Distribution Statement : APPROVED FOR PUBLIC RELEASE