Accession Number : AD0622292

Title :   REACTION OF 4-FORMYL-1-METHYL PYRIDINIUM IODIDE OXIME (4-PAM) WITH ISOPROPYL METHYLPHOSPHONOFLUORIDATE, GB.

Descriptive Note : Technical rept. for Aug 56-Jun 58,

Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s) : Lamb,J. C. ; Steinberg,G. M. ; Solomon,S. ; Hackley,B. E. ,Jr.

Report Date : AUG 1965

Pagination or Media Count : 33

Abstract : The reaction of GB with 4-formyl -1-methylpyridinium iodide oxime (4-PAM), a model treatment compound for anticholinesterase poisoning, in near-neutral aqueous solution yields O-(isopropyl methylphosphono)-4-formyl1-methylpyridinium iodide oxime (4-PPAM). Its rate of formation is defined by the relationship dx/dt = k (GB) (4-PAM anion), where k = 885 = 70/M/min, 30 C, pH 7.6, 0.1 M KNO3. 4-PPAM is stable in acidic and neutral aqueous solution. Its decomposition in alkaline solution is defined by the relationship dx/dt = k (OH) (4-PPAM), where k = 8600/M/min, 30 C, 0.1 M KC1. 4-PPAM is a potent anticholinesterase. Its decomposition in nearneutral aqueous solution is speeded by imidazole, 4-PAM, bicarbonate, and two hydroxamic acids. (Author)

Descriptors :   (*G AGENTS, CHEMICAL REACTIONS), (*CHOLINESTERASE INHIBITORS, CHEMICAL REACTIONS), ORGANIC PHOSPHORUS COMPOUNDS, OXIMES, IODIDES, THERAPY, IONS, HYDROXAMIC ACIDS, DECOMPOSITION

Distribution Statement : APPROVED FOR PUBLIC RELEASE