Accession Number : AD0623005

Title :   INCREASED PLASMA-CHOLINESTERASE ACTIVITY AND SUCCINYLCHOLINE RESISTANCE: A GENETIC VARIANT.

Descriptive Note : Rept. for Aug 64-Jun 65,

Corporate Author : CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s) : Neitlich, Harvey W. ; Mounter,L. A.

Report Date : OCT 1965

Pagination or Media Count : 27

Abstract : Plasma-cholinesterase activity was determined in medical-volunteer-program subjects. In 1,029 subjects, activity varied from 92 to 1,278 micromoles ACH hydrolyzed/hr, with a mean of 391 micromoles. Plasmacholinesterase activity in one subject was consistently elevated. Examination of his family revelaed that this activity was inherited in an autosomal, dominant manner. In vitro and in vivo studies suggested that the propositus was heterozygous for an enzyme molecule more than three times as active as the usual cholinesterase. The pharmacological effect of this genetic variation is discussed. (Author)

Descriptors :   (*CHOLINESTERASE, REACTION KINETICS), ENZYMES, CHOLINESTERASE INHIBITORS, PARENTERAL INFUSIONS, ELECTROPHORESIS, BLOOD ANALYSIS, INHIBITION, GENETICS, MUSCLE RELAXANTS

Distribution Statement : APPROVED FOR PUBLIC RELEASE