Accession Number : AD0623345

Title :   MUTAGENICITY OF CYTOSINE FOR AN ADENINE AND ARGININE REQUIRING STRAIN OF CADIDA ALBICANS,

Corporate Author : WICHITA STATE UNIV KANS DEPT OF BIOLOGY

Personal Author(s) : Sarachek,A.

Report Date : 1965

Pagination or Media Count : 8

Abstract : An adenine-arginine double auxotroph of Candida albicans exhibits increased back mutation to arginine independence when cultivated in the presence of growth inhibiting levels of cytosine. Of the natural nucleic acid bases, only adenine or guanine relieve growth inhibition and mutation; adenine is more effective than guanine in relieving inhibition but less effective than guanine in preventing mutation. Previous studies have shown that cytosine renders adenine auxotrophs of C. albicans purine deficient by competitively interfering with their utilization of exogenous adenine. The mutagenic effect of cytosine reported here is attributed to a cytosine induced cellular deficiency for guanine which favors the erroneous incorporation into replicating DNA of other nucleotides in place of the guanine nucleotide. (Author)

Descriptors :   (*CANDIDA, MUTATIONS), (*MUTATIONS, DEOXYRIBONUCLEIC ACIDS), (*NUCLEOTIDES, CANDIDA), AMINO ACIDS, ADENINE, GUANINE, GROWTH(PHYSIOLOGY), INHIBITION, PURINES, NUCLEIC ACIDS, CULTURE MEDIA, PYRIMIDINES

Distribution Statement : APPROVED FOR PUBLIC RELEASE