Accession Number : AD0623367

Title :   5-HYDROXTRYPTAMINE RECEPTORS AND SYNAPTIC TRANSMISSION IN MOLLUSCAN NEURONES,

Corporate Author : BUENOS AIRES UNIV (ARGENTINA) INSTITUTO DE ANATOMIA GENERAL Y EMBRIOLOGIA

Personal Author(s) : Gerschenfeld,H. M. ; Stefani,E.

Report Date : 1965

Pagination or Media Count : 6

Abstract : The high 5-hydroxytryptamine (5-HT) mollusc ganglia (which is here confirmed for the Argentine land snail Cryptomphallus aspersa), the presence of enzymes for the synthesis and inhibition of 5-HT, the specific effects of the amine on the membrane conductance of cells with inhibition of long diration (CILDA), and the presence of specific 5-HT receptors on the membrane of the same neuron type fill some of the criteria required to consider the substance as a synaptic transmitter. The blocking of 5-HT receptor sites by lysergic acid diethylamide and by bromolysergic acid was confirmed on the cellular level with CILDA neurones. Additional evidence indicates that 5-HT may be the natural excitatory transmitter for these neurones.

Descriptors :   (*MOLLUSCA, NERVOUS SYSTEM), (*GASTROPODA, NERVOUS SYSTEM), (*NERVE CELLS, PHYSIOLOGY), (*SEROTONIN, NERVE IMPULSES), AMINES, ALCOHOLS, CHEMORECEPTORS, MEMBRANES(BIOLOGY), ACETYLCHOLINE, ENZYMES, BIOSYNTHESIS, GANGLIA, LYSERGIC ACIDS, ARGENTINA

Distribution Statement : APPROVED FOR PUBLIC RELEASE