Accession Number : AD0623481

Title :   CLINICAL PATHOLOGICAL CORRELATIONS IN SQUIRREL MONKEYS AFTER SUPPRESSION OF SEMICIRCULAR CANAL FUNCTION BY STREPTOMYCIN SULFATE.

Descriptive Note : Research rept.,

Corporate Author : NAVAL SCHOOL OF AVIATION MEDICINE PENSACOLA FLA

Personal Author(s) : Igarashi,Makoto ; mcLeod,Michael E. ; Graybiel,Ashton

Report Date : JUL 1965

Pagination or Media Count : 39

Abstract : Streptomycin sulfate was injected to eight selected squirrel monkeys in sufficient dosage to cause suppression of canal function as indicated by the threshold caloric test, emesis in the Slow Rotation Room, and ataxia. The animals were sacrificed six months after the suppression and slides for light-microscopic investigation were prepared following the standard temporal bone preparation procedure. Pathological findings were confined largely to the cristae and organ of Corti, which were both involved in almost every case. Only very slight changes were observed in the maculae in a few instances; therefore, this drug has a place in vestibular studies requiring selective suppression of canal function. The clinical tests used were not reliable indicators of the pathophysiological state of the cristae but were fairly reliable indicators of normal function of these organs. With regard to emesis in the SRR and ataxia, the essentiality of normal function of the semicircular canals has been demonstrated. No such essentiality was demonstrated for the otolith organs in the present investigation. (Author)

Descriptors :   (*VESTIBULAR APPARATUS, STREPTOMYCINS), (*STREPTOMYCINS, VESTIBULAR APPARATUS), (*SEMICIRCULAR CANALS, STREPTOMYCINS), PATHOLOGY, EAR, MUSCULOSKELETAL SYSTEM, DISEASES, EMESIS, DOSAGE, THRESHOLDS(PHYSIOLOGY), TOXICITY, MONKEYS

Distribution Statement : APPROVED FOR PUBLIC RELEASE