Accession Number : AD0624917

Title :   THE SEQUENCE OF EVENTS IN RADIATION CARCINOGENESIS: A UNIFYING FORMULATION,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Cole,Leonard J. ; Nowell,Peter C.

Report Date : 02 NOV 1965

Pagination or Media Count : 30

Abstract : First, one or more specific mutations are produced in the target cell, either directly or through an indirect mechanism, viral or otherwise. Tumor development begins when the altered cell, having survived the mutating event, is brought into mitosis by a specific or nonspecific proliferative stimulus. Subsequent tumor progression results from repeated additional mutations in the tumor cells with sequential clonal selection from the altered population. Considerations of radiation carcinogenesis in experimental animals, and presumably in man as well, must include the effects of total dose, dose rate and quality of radiation on mutagenesis, and on the survival of mutated cells; and the effects and interactions of both mutagenic and nonmutagenic agents (including viruses, hormones, other environmental factors, and radiation itself) on subsequent tumor development. It is concluded that the complex interplay of many factors and mechanisms--indirect as well as direct--in radiation carcinogenesis makes a simple dose-response relationship untenable. (Author)

Descriptors :   (*CANCER, RADIATION SICKNESS), (*RADIATION, CANCER), RADIATION HAZARDS, MUTATIONS, CELLS(BIOLOGY), RADIATION EFFECTS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE