Accession Number : AD0625943

Title :   IMMUNOLOGICAL ASPECTS OF EXPERIMENTAL TOXOPLASMOSIS.

Descriptive Note : Semi-annual rept. 28 May-27 Nov 64,

Corporate Author : KEIO UNIV TOKYO (JAPAN) SCHOOL OF MEDICINE

Personal Author(s) : Matsubayashi,Hisakichi

Report Date : 27 NOV 1964

Pagination or Media Count : 6

Abstract : Mice which survived a prior infection with low virulent toxoplasmas (Beverley strain) tolerated a challenge infection with a highly virulent strain (RH strain). Of 35 mice which survived the challenge infection with RH, the brains of 22 of these mice were shown to contain living organisms. Vaccination with heat-killed Toxoplasma alone or in incomplete adjuvants seemed to have no effect in increasing the protection of the mice against a challenge RH infection. Vaccination with sonic disrupted Toxoplasma also failed to protect mice against a RH challenge. Passive immunization with anti-toxoplasma sera obtained from infected rabbits and pigs demonstrated very little effects in prolongation of the survival period of infected mice. Development of cellular immunity to some degree was indicated by the experiments employing implanted diffusion chambers in the peritoneal cavity of mice. The role of antibody in the formation of the cyst of Toxoplasma was investigated. The anti-metabolite 6-mercaptopurine was inoculated into infected mice in order to inhibit the normal immune response of the mice to the parasite. The results tend to indicate that antibody is not an essential prerequisite to cyst formation. (Author)

Descriptors :   (*TOXOPLASMA, IMMUNITY), IMMUNOLOGY, DISEASES, INFECTONS, TOLERANCES(PHYSIOLOGY), VACCINES, IMMUNE SERUMS, ANTIGENS + ANTIBODIES, ANTIMETABOLITES, MICE, JAPAN

Subject Categories : Medicine and Medical Research
      Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE