Accession Number : AD0625951

Title :   EPIDEMIOLOGICAL AND GENETICAL STUDY ON THE DRUG-RESISTANCE OF SHIGELLAE AND STAPHYLOCOCCI.

Descriptive Note : Semi-annual rept., 15 May-14 Nov 64,

Corporate Author : INSTITUTE OF MICROBIAL CHEMISTRY TOKYO (JAPAN)

Personal Author(s) : Mitsuhashi,Susumu

Report Date : 14 NOV 1964

Pagination or Media Count : 5

Abstract : From the in-patients of 6 city hospitals, 6,000 strains of Shigella were isolated, and their bacteriological properties and drug-resistance patterns were examined. Approximately 90% of the isolated Shigella strains were resistant to sulfanilamide (SA). Among the drug-resistant Shigella strains, 78% were resistant to chloramphenicol(CM), tetracycline(TC), streptomycin(SM) and sulfanilamide(SA). A transmissible drug-resistance factor, R(CM(s)TC(s)SM(r)SA(r) was obtained from an epidemic in Tokyo. Following the administration of tetracycline, R(CM(s)TC(r)SM(r) SA(r) was obtained from the same patients. It was found by in vitro study that R(CM(s)TC(s)SM(r)SA(r) factor was converted to R(CM(s)TC(r)SM(r)SA(r) factor in high frequency on the plate containing tetracycline. From the in-patients of 14 hospitals, 1284 strains of staphylococci were isolated, and their phase typing and drug-resistance patterns were examined. Ninety-nine percent were drug-resistant. Among the resistant strains, 31% were resistant to SA, 20% to PC.SA, 17% to TC.SM.PC.SA, and 12% to TC.PC.SA. It was noted that the degree of resistance to each drug was extremely high in the multiple resistant strains.

Descriptors :   (*DRUGS, RESISTANCE(BIOLOGY)), (*SHIGELLA, ANTIBIOTICS), (*STAPHYLOCOCCUS, ANTIBIOTICS), GENETICS, EPIDEMIOLOGY, IN VITRO ANALYSIS, CHLORAMPHENICOL, TETRACYCLINES, STREPTOMYCINS, PENICILLINS, JAPAN

Subject Categories : Microbiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE