Accession Number : AD0629512

Title :   X-RAY INDUCED GLOMERULOSCLEROSIS IN RATS: MODIFICATION OF LESION BY FOOD RESTRICTION, UNINEPHRECTOMY, AGE,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Wachtel,L. W. ; Cole,L. J. ; Rosen,V. J. ,Jr.

Report Date : 11 FEB 1966

Pagination or Media Count : 20

Abstract : The development of glomerulosclerosis was measured in the kidneys of rats under various conditions of irradiation and growth. Weanling rats showe kidneys were irradiated directly with 1,000 rad or 2,000 rad developed glomerulosclerotic lesions in 2 months; one-year old rats showed no evidence of lesions 2 months after irradiation with 2,000 rad. In the weanling rat the rapidity of development and severity of the glomerulosclerotic lesions were increased by growth or enlargement of the kidney subsequent to irradiation, and were slowed by growth retardation artificially produced through low-food intake. The induction of glomerulosclerosis by X-irradiation of the kidney is believed to be a latent result of damage to the kidney's vascular system, and that effects of this damage are accentuated in the growing kidney. (Author)

Descriptors :   (*RADIATION EFFECTS, KIDNEYS), (*KIDNEYS, RADIATION EFFECTS), PATHOLOGY, FOOD, DIET, AGING(PHYSIOLOGY), X RAYS, RADIATION INJURIES, GROWTH(PHYSIOLOGY), BODY WEIGHT, BLOOD VESSELS, DEOXYRIBONUCLEIC ACIDS, RADIATION DOSAGE, EXCISION, RATS

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE