Accession Number : AD0629548

Title :   ANTIARRHYTHMIC ACTIVITY OF ANTAZOLINE AND ITS APPLICATION TO THE CONTROL OF HYPOTHERMIC VENTRICULAR FIBRILLATION.

Descriptive Note : Final rept. Feb 63-Apr 65,

Corporate Author : BOSTON UNIV MASS HYPOTHERMIA LAB

Personal Author(s) : Angelakos,E. T.

Report Date : DEC 1965

Pagination or Media Count : 37

Abstract : The chemistry and general pharmacology of antazoline and experimental studies employing it are reviewed to determine the antiarrhythmic activity and the protective effect of antazoline against hypothermic ventricular fibrillation. In hypothermic ventricular fibrillation and in clinically observed heart disorders, the antiarrhythmic activity of antazoline was often superior to other pharmacological agents, including quinidine. The incidence of side effects, notably nausea or vomiting, was found to be related to the dosage. Since the basis of the antiarrhythmic activity of antazoline is essentially unknown, further studies in this direction are warranted to provide for systematic development of more effective compounds. (Author)

Descriptors :   (*HYPOTHERMIA, ARRHYTHMIA), (*ARRHYTHMIA, ANTIHISTAMINICS), HEART, PATHOLOGY, PHARMACOLOGY, DOSAGE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE