Accession Number : AD0630103

Title :   EFFECTS OF TOTAL-BODY X IRRADIATION ON PERITONEAL AND CIRCULATING LEUCOCYTES OF MICE,

Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s) : Kornfeld,Lottie ; Greenman,Vivian

Report Date : 13 JAN 1966

Pagination or Media Count : 26

Abstract : Total-body X irradiation over a wide range of doses was found to alter the number and distribution of cells in the peritoneal cavity of unstimulated LAF-1 mice. Unirradiated controls yielded 5-7 x 10 to the 6th power mononuclear cells, about 30% of which were macrophages and 70% small and medium lymphocytes. Following exposure to sublethal X ray doses (90-590 R), macrophage counts were essentially unaltered for two weeks but declined slightly during the 3rd week after 390-590 R. Following a midlethal dose (690 R), the number of macrophages was unchanged for one week but fell to about 50% of the normal value by 21 days postirradiation. After lethal irradiation (790-1190 R), macrophage counts remained unaltered for 3 days but decreased on the 7th day. The number of lymphocytes in the peritoneal cavity decreased sharply within 24 hours after every dose employed and then declined further at a more gradual rate. Both the initial and the subsequent disappearance of lymphocytes increased in severity with increasing exposure. During the first week postirradiation, a linear relation existed between the percentage of lymphocytes in the peritoneal cell population and the X ray dose. (Author)

Descriptors :   (*LEUKOCYTES, RADIATION EFFECTS), (*X RAYS, WHOLE BODY IRRADIATION), PERITONEUM, MICE, BLOOD CIRCULATION, CELLS(BIOLOGY), PHAGOCYTES

Subject Categories : Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE